Open AccessSpecific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132
Author(s) -
Jamie L. Lahvic,
Michelle Ammerman,
Pulin Li,
Megan C. Blair,
Emma Stillman,
Eva M. Fast,
Anne L. Robertson,
Constantina Christodoulou,
Julie R. Perlin,
Song Yang,
Nan Chiang,
Paul C. Norris,
Madeleine L. Daily,
Shelby E. Redfield,
Iris T. Chan,
Mona Chatrizeh,
Michael E. Chase,
Olivia Weis,
Yi Zhou,
Charles N. Serhan,
Leonard I. Zon
Publication year - 2018
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.1806077115
Subject(s) - vertebrate , haematopoiesis , receptor , microbiology and biotechnology , chemistry , biology , zoology , biochemistry , stem cell , gene
Significance Small-molecule enhancers of hematopoietic stem cell transplant could improve the safety of this treatment and expand the pool of eligible patients. We previously showed that the lipid 11,12-epoxyeicosatrienoic acid (EET) enhanced transplant in zebrafish and mice. We use a bioinformatic approach to identify candidate EET receptors and demonstrate that EET activates GPR132. We find that this receptor is important in zebrafish and mouse hematopoiesis, and we further show that GPR132 has responsiveness to additional oxygenated polyunsaturated fatty acids such as EET. Thus, GPR132 receives lipid-derived signals to regulate hematopoiesis and is a therapeutic target for enhancing HSC transplant.
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