English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Significance Osteoclasts play an essential role in bone homeostasis. Understanding how osteoclast differentiation is regulated is important in the context of pathological bone conditions and the hematopoietic stem cell (HSC) niche. We show that PTIP directly promotes chromatin changes required forPparγ expression, a transcription factor essential for osteoclastogenesis. Deletion of PTIP disrupts the integrity of the bone marrow (BM) niche, leading to a reduction of HSCs in the BM. Furthermore, a PTIP-deficient BM microenvironment decreases the number of acute myeloid leukemia-initiating cells in the BM and increases survival upon transplantation. Taken together, our data identify PTIP as an epigenetic regulator of osteoclastogenesis that is required for the integrity of the BM niche to sustain both normal hematopoiesis and leukemia.

Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches