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Significance For influenza virus to release from the infected host cell, controlled viral budding must finalize with membrane scission of the viral envelope. Curiously, influenza carries its own protein, M2, which can sever the membrane of the constricted budding neck. Here we elucidate the physical mechanism of clustering and spatial localization of the M2 scission proteins through a combined computational and experimental approach. Our results provide fundamental insights into how M2 clustering and localization interplay with membrane curvature, membrane lateral stresses, and lipid bilayer phase behavior during viral budding to contribute to virion release.

Entropic forces drive clustering and spatial localization of influenza A M2 during viral budding