Open AccessMouse and human urothelial cancer organoids: A tool for bladder cancer research
Author(s) -
Jasper Mullenders,
Evelien de Jongh,
Anneta Brousali,
Mieke Roosen,
Jan P. A. Blom,
Harry Begthel,
Jeroen Korving,
Trudy Jonges,
Onno Kranenburg,
Richard P. Meijer,
Hans Clevers
Publication year - 2019
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.1803595116
Subject(s) - organoid , bladder cancer , cancer , medicine , urothelial cancer , personalized medicine , biobank , pathology , cancer research , oncology , biology , bioinformatics , neuroscience
Significance Bladder cancer poses a big clinical challenge, particularly in advanced cases. Here we present a culture system for bladder cancer based on organoid culture technology. We have created a living biobank containing organoids grown from over 50 patient samples, which reflects many aspects of bladder cancer pathogenesis. Organoids of human bladder cancer cells can be maintained for prolonged periods of time, and closely resemble the tumor histology. Bladder organoids can be used for drug screening, and therefore provide a platform for development of new drugs for the treatment of bladder cancer and personalized medicine.
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