Open AccessLong noncoding RNA SYISL regulates myogenesis by interacting with polycomb repressive complex 2
Author(s) -
Jianjun Jin,
Wei Lv,
Pan Xia,
Zai Yan Xu,
An Zheng,
XiaoJing Wang,
Shanshan Wang,
Rui Zeng,
Hong Luo,
Guoliang Li,
Bo Zuo
Publication year - 2018
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.1801471115
Subject(s) - myogenesis , prc2 , biology , c2c12 , myogenin , myocyte , ezh2 , gene silencing , microbiology and biotechnology , facioscapulohumeral muscular dystrophy , polycomb group proteins , epigenetics , gene , repressor , gene expression , genetics
Significance While numerous long noncoding RNAs (lncRNAs) have been identified in muscle, most of their roles in myogenesis remain unclear, and many more lncRNAs have yet to be identified. In this study, we identified an intronic lncRNA,SYISL (SYNPO2 intron sense-overlapping lncRNA), which is highly expressed in muscle and interacts directly with polycomb repressive complex 2 (PRC2) to repress muscle development. The results reveal thatSYISL acts as a regulatory RNA in PRC2-mediated myogenesis.
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