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Significance While numerous long noncoding RNAs (lncRNAs) have been identified in muscle, most of their roles in myogenesis remain unclear, and many more lncRNAs have yet to be identified. In this study, we identified an intronic lncRNA,SYISL (SYNPO2 intron sense-overlapping lncRNA), which is highly expressed in muscle and interacts directly with polycomb repressive complex 2 (PRC2) to repress muscle development. The results reveal thatSYISL acts as a regulatory RNA in PRC2-mediated myogenesis.

Long noncoding RNA SYISL regulates myogenesis by interacting with polycomb repressive complex 2