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Significance The search for new obesity drug targets and the rediscovery of active brown fat (brown adipose tissue; BAT) in adult humans has triggered a BAT renaissance. However, the assumption that this tissue plays a key role in energy balance in humans, as it does in rodents, is still a matter of debate. This is because BAT mass cannot be correctly quantified by current imaging techniques, as these are either nonspecific or lack the necessary sensitivity to detect BAT, especially in obese phenotypes. Here, we show that xenon-enhanced computed tomography can accurately quantify BAT mass, especially in obese mouse phenotypes in which extensive BAT hypertrophy hampers the detection of this tissue by current tomographic imaging techniques.

Accurate quantification of brown adipose tissue mass by xenon-enhanced computed tomography