Open AccessAntagonistic regulation of trafficking to Caenorhabditis elegans sensory cilia by a Retinal Degeneration 3 homolog and retromer
Author(s) -
Luis Martinez-Velazquez,
Niels Ringstad
Publication year - 2017
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.1712302115
Subject(s) - cilium , caenorhabditis elegans , biology , sensory system , retinal degeneration , microbiology and biotechnology , degeneration (medical) , sensory neuron , neuroscience , mechanosensation , genetic screen , retina , genetics , gene , phenotype , ion channel , pathology , receptor , medicine
Significance Sensory neurons concentrate the molecular machinery of sensation into a specialized cellular antenna: the cilium. Proteins destined for the cilium are synthesized in the cell body, and poorly understood mechanisms separate them from other cellular proteins and target them to the cilium. Through genetic studies of this process in sensory neurons of the nematodeCaenorhabditis elegans , we show that a sensory neuron-specific factor that mutates in humans to cause photoreceptor degeneration and blindness regulates an early stage in the trafficking of a key molecule for sensation.
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