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Significance The antiparallel nature of the two strands in duplex DNA poses a topological problem for their simultaneous synthesis. The “trombone” model of the replication fork postulates that the lagging-strand forms a loop such that the leading- and lagging-strand replication proteins contact one another. The replisome then can move in one direction along the DNA while synthesizing both strands. Physical interactions between the replication proteins and DNA coordinate processive synthesis of the leading and lagging strands. Here, we present the structure of a functional replisome from bacteriophage T7. Our structural and biochemical analyses provide an explanation of the mechanisms governing coordination of leading- and lagging-strand synthesis.

Cryo-EM structure of the replisome reveals multiple interactions coordinating DNA synthesis