English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Microprocessor components are transported into the nucleus to process primary miRNAs (pri-miRNAs). Hyponastic leaves 1 (HYL1) is a core component of microprocessor inArabidopsis . This study identifies an importin β-protein, KETCH1, as a partner of HYL1 protein.KETCH1 knockdown mutation causes developmental defect, reminiscent of mutants in the miRNA pathway. The mutation also reduces miRNA abundance but does not affect its nuclear-cytoplasmic distribution. Rather,KETCH1 knockdown mutation decreases the accumulation of HYL1 protein in the nucleus and compromises the HYL1-mediated pri-miRNA processing, supporting that KETCH1 specifically transports HYL1 into the nucleus to facilitate miRNA production. Given that HYL1 and importin β-proteins are all conserved in various organisms, this study sheds light on the poorly understood nuclear-cytoplasmic trafficking of microprocessor components through eukaryotes.

KETCH1 imports HYL1 to nucleus for miRNA biogenesis in Arabidopsis