English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Novel approaches have reinvigorated the search for the elusive memory engram—and energized attempts to control it. What is a memory? Can it be purposefully erased, implanted, or altered? Such musings have long captured the public imagination, inspiring cinematic tales of memory manipulation, ranging from the political thriller The Manchurian Candidate, to the sci-fi classic Total Recall. In the quirky romance Eternal Sunshine of the Spotless Mind, memory technicians erase painful recollections of failed relationships. In Inception, memory mercenaries slip into a businessman’s dreams to surreptitiously plant an idea. Can memory be purposefully erased, implanted, or altered? Numerous research groups are keen to find out. Image courtesy of Dave Cutler (artist). Memory-tweaking experiments in the laboratory, although decidedly more prosaic, are nevertheless yielding dramatic results. In 2013, Susumu Tonegawa at the Massachusetts Institute of Technology in Cambridge, and his colleagues stimulated certain neurons in the hippocampus of mice, demonstrating that the researchers could plant a fearful memory of being shocked on the foot in an environment where no shock had actually occurred (1). This work was a powerful demonstration of the access and control that neuroscientists are gaining over the once-elusive engram, the physical embodiment of a memory in the brain. Ever since the idea was first formalized in the early 1900s, researchers have struggled to capture and elucidate the engram. Neuroscientists theorized that memory would leave behind some physical imprint, a structural, electrical, or biochemical change by which networks of neurons might retain information for hours, months, or years. Researchers collected pieces of this puzzle over the years, identifying molecules, genes, and cellular processes that are important for learning and memory. Since discoveries in the 1960s and 1970s, many have suggested that memory is supported by long-term potentiation, an effect by which neurons that fire together …

To master memory, researchers pursue its roots