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Significance During mammalian cell division, the contiguous Golgi ribbon is first vesiculated and then partitioned into the daughter cells with the aid of the mitotic spindle. Whether Golgi vesiculation is required for cell division is unclear. Here, we show that inhibition of Golgi disassembly by the acute formation of a polymer in the Golgi lumen prior to mitotic entry blocks bipolar spindle formation and arrests cells in early mitosis with an active spindle assembly checkpoint (SAC). Importantly, mitotic progression is fully restored upon depletion of centrosomes. Our work thus reveals that mitotic Golgi disassembly is tightly monitored and acts as an upstream surveillance point for the canonical SAC to ensure the fidelity of Golgi inheritance and cell division.

Mitotic Golgi disassembly is required for bipolar spindle formation and mitotic progression