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Menghi et al. (1) report a metric to classify tumors into those with and without a tandem duplicator phenotype (TDP), using the frequency of tandem duplications (TDs) in 277 whole-genome sequenced samples. Building on a previous method (2), Menghi et al. (1) identified TDs from SNP array data, and found that the TDP was strongly associated with response to the DNA damaging chemotherapeutic, cisplatin. These findings supplement the growing recognition that genome-wide signatures of mutator phenotypes may prove to be important additions to the companion diagnostic repertoire (3, 4). Although the findings of this report are highly stimulating, accumulating evidence suggests that an elevated abundance of TDs features in not just one but two distinct phenotypes.Two of the original studies on the TDP reported a mutual exclusion with breast cancer 1/2 ( BRCA1/2 ) inactivation (2, 5), which conflicts … [↵][1]1To whom correspondence should be addressed. Email: anita.grigoriadis{at}kcl.ac.uk. [1]: #xref-corresp-1-1

Tandem duplications contribute to not one but two distinct phenotypes