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Significance Neurons that innervate the inner ear originate as neuroblasts in the otic vesicle, the epithelial precursor of the inner ear. Neuroblasts subsequently delaminate from the otic epithelium to complete differentiation near the hindbrain. Despite growing understanding of otic neurogenesis, the mechanism by which neuroblasts delaminate from the otic vesicle is unknown. Here we show that delamination is triggered byGoosecoid (Gsc ), a homeobox gene famously discovered as the first known regulator of the “Spemann” embryonic organizer.Gsc is expressed in the otic vesicle in a region overlapping with neuroblasts, inducing localized epithelial-to-mesenchymal transition (EMT). Hence, regulation of cellular dynamics appears to be a general function ofGsc during otic neurogenesis as well as in the embryonic organizer.

Spemann organizer gene Goosecoid promotes delamination of neuroblasts from the otic vesicle