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Significance Mice and humans whose T cells are deficient in NFκB signaling lack memory T cells, but the mechanism behind this is unclear. We found that NFκB signaling is required during the resolution phase of the immune response to maintain long-term CD8 memory. NFκB signaling is necessary for preserving expression of Eomesodermin and prosurvival Bcl-2 in memory T cells, in a cell-intrinsic process where T-cell receptor (TCR) signals and Pim-1 kinase are involved. Our study defines an unexpected role of NFκB and Pim-1 signaling in the maintenance of T-cell memory quality. Furthermore, it identifies targets and specific times of intervention where protective T-cell memory could be reinforced in vaccines and cancer immunotherapies by manipulation of the NFκB–Pim-1–Eomesodermin axis.

NFκB–Pim-1–Eomesodermin axis is critical for maintaining CD8 T-cell memory quality