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Significance Lung cancer is the leading cause of cancer death worldwide. Lung squamous cell carcinoma (SCCa) is classified as central or peripheral, according to the location of the primary tumor. Peripheral SCCa (PSCCa) is becoming as common as central SCCa, but the reasons for this increase are unclear. Smoking and chronic lung inflammation are recognized as risk factors for lung cancer.LXR α,βDko mice accumulate lipid in their lungs and develop M1-macrophage-predominant chronic lung inflammation and eventually lesions resembling PSCCa. This mouse model may provide a tool to study the etiology and progression of lung PSCCa and suggests a need for examination of LXR signaling in human PSCCa.

Ablation of Liver X receptors α and β leads to spontaneous peripheral squamous cell lung cancer in mice