Description of USP12 nuclear export sequence
Author(s) -
José Antonio Rodríguez
Publication year - 2016
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.1606081113
Subject(s) - sequence (biology) , computational biology , computer science , biology , genetics
In PNAS, Jahan et al. (1) describe a new role for the ubiquitin-specific protease 12 (USP12) deubiquitinase in T-cell receptor (TCR) signaling. Among other findings, the authors report that USP12 is exported from the nucleus to the cytosol upon TCR activation. Although the experimental evidence they provide is consistent with this model, I believe that some of their results would require a more detailed description to support their claims better.
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