English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Gastric cancer is the third leading cause of cancer mortality, with an overall 5-y survival rate of &lt;25%. Although sequencing and comprehensive molecular profiling of human gastric cancer have identified a wide spectrum of genes that drive gastric cancer development, we are still far from understanding the complete pathophysiology of this disease. Here, we usedSleeping Beauty transposon mutagenesis to identify genes and evolutionary forces driving gastric cancer development. This study identified pathways driving gastric cancer development, including WNT, TGF-β, PI3K signaling, ubiquitin-mediated proteolysis, adherens junctions, RNA degradation, and chromatin modification, and discovered many previously unidentified genes, such as the LDL receptor-related protein 1B (LRP1B ) tumor suppressor gene, with potential clinical importance in human gastric cancer.

Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development