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Significance Pectin and alginate are polysaccharides found in the cell walls of plants and brown algae, respectively. These polysaccharides largely consist of chains of uronates, which can be metabolized by bacteria through a pathway of enzymatic steps to the key metabolite 2-keto-3-deoxygluconate (KDG). Understanding the metabolism of these sugars is important because pectin degradation is used by many plant-pathogenic bacteria during infection, and both pectin and alginate represent abundant sources of carbohydrate for the production of biofuels. Here we demonstrate that KdgF, a protein of previously unknown function, catalyzes the linearization of unsaturated uronates from both pectin and alginate. Furthermore, we show that KdgF contributes to efficient production of KDG and a bacterium’s ability to grow on uronates.

KdgF, the missing link in the microbial metabolism of uronate sugars from pectin and alginate