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Significance We previously demonstrated that the microtubule (MT) motor protein kinesin-1 slides and transports MTs themselves in addition to its established role in organelle transport. However, the physiological importance of MT sliding has not been determined. Here, we identified the mechanism of kinesin-1–based MT sliding and generated a sliding-deficientDrosophila mutant. Additionally, we generated a chimeric motor that actively slides MTs but cannot transport organelles. Using these tools, we demonstrated that MT sliding is an essential biological process, with key roles in both axon and dendrite outgrowth. Because the C-terminal MT-binding site of kinesin-1, which is essential for sliding, is highly conserved in vertebrates and invertebrates, we postulate that MT sliding is important for nervous system development in many organisms.

Role of kinesin-1–based microtubule sliding in Drosophila nervous system development