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Significance Although full mammalian limbs do not regenerate after amputation, the fingertips of select mammalian species do. Understanding digit tip regeneration at the molecular level can potentially provide insight into designing translational therapies for regrowing greater portions of the limbs and other nonregenerative tissues. The nail is known to be critical for digit tip regeneration, at least in part through a mechanism dependent on Wnt signaling. Here, we identify a cell population expressing a mediator of Wnt signaling, Lgr6 (leucine-rich repeat-containing G protein-coupled receptor 6), as key stem cells for the nail. Moreover, we find thatLgr6 is required for proper digit tip regeneration.

Lgr6 marks nail stem cells and is required for digit tip regeneration