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Bowen and Casadevall (1) offer data suggesting that research inputs have not been associated with comparable increases in health outcomes over the past five decades. However, their analysis treats biomedical research the same, regardless of whether the research focuses on early phases, (i.e., basic discovery) or late phases, (i.e., comparative effectiveness and implementation and dissemination research). The most direct way to improve the relationship between research input and health outcomes is to focus on “pushing out” …

Distinguishing phases of biomedical research is critical to improving health outcomes