G s α deficiency in adipose tissue improves glucose metabolism and insulin sensitivity without an effect on body weight

Significance The G protein Gs α mediates the activation of lipolysis in white and brown adipose tissue (WAT and BAT) and thermogenesis in BAT by sympathetic nerves. In this study we show that Gs α deficiency in BAT and WAT leads to cold intolerance and inactive BAT in mice, as expected, but does not alter body weight or energy balance, associated with a reduction in both lipolysis and lipogenesis. Despite having similar adiposity, these mice had improved insulin sensitivity and glucose metabolism, possibly secondary to reduced release of free fatty acids and fatty acid binding protein 4 from adipose tissue. These findings show that Gs α in adipocytes is not required to maintain energy balance but still has an important effect on glucose metabolism.