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Significance Gene silencing by Polycomb group (PcG) proteins is required to maintain tissue and stage-specific patterns of gene expression. PcG complexes assemble on special elements, Polycomb response elements (PREs), and function to silence gene activity in the surrounding domain. The activity of PREs is subject to regulation and can be epigenetically switched from “on” (silencing) to “off” (permissive for transcription) as development proceeds. Previous studies suggested that a burst of transcription through a PRE displaces PcG complexes, switching the PRE off in a heritable fashion. Here, we directly tested the transcription read-through hypothesis. We show that transcription through a PRE is not sufficient for induce a heritable switch. In fact, continuous transcription through a PRE fails to displace PcG complexes or eliminate repressive chromatin marks.

Transcriptional read-through is not sufficient to induce an epigenetic switch in the silencing activity of Polycomb response elements