English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Major histocompatibility complex (MHC) molecules play crucial roles in the immune response to pathogens and tumors by presenting protein fragments (peptides) to T lymphocytes. Recently, it has become clear that the breadth of peptide presentation by MHC class I molecules is inversely correlated with the level of cell surface expression, a relationship that is correlated with resistance to Marek’s disease in chickens and with progression to AIDS in humans. In this article, evidence is presented that class I molecules vary in a suite of correlated properties, including thermostability, that are influenced, at least in part, by the breadth of peptide translocation by the transporters for antigen presentation (TAPs) that pump peptides to be loaded.

Surface expression, peptide repertoire, and thermostability of chicken class I molecules correlate with peptide transporter specificity