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Parkinson’s disease (PD) is the second most common neurodegenerative disease in the elderly. Santiago and Potashkin (1) recently performed a network-based metaanalysis of four independent microarray datasets and identified hepatocyte nuclear factor 4 alpha (HNF4A) and polypyrimidine tract binding protein 1 (PTBP1) to be the longitudinally dynamic biomarkers for PD. They found that HNF4A is a central regulatory hub gene up-regulated in blood of PD patients and PTBP1 is the most down-regulated gene (1). It is reported that …

Expression quantitative trait loci regulate HNF4A and PTBP1 expression in human brains