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Significance The postgenomic era has seen the identification of numerous long noncoding RNA (lncRNAs) in mammalian cells; however, their biological functions remain largely unknown. Nuclear paraspeckle assembly transcript 1 (NEAT1) is an lncRNA that participates in the construction of the massive ribonucleoprotein subnuclear complex, the paraspeckle. Paraspeckle formation proceeds in conjunction with NEAT1 biogenesis and the assembly of &gt;40 proteins. Here, we demonstrate that SWItch/Sucrose NonFermentable (SWI/SNF) chromatin-remodeling complexes play an essential role in organizing the protein–protein interaction network of paraspeckles in a manner that does not require their canonical remodeling activity. We also show that SWI/SNF complexes are required for the assembly of the Satellite III lncRNA-dependent nuclear stress body. These data suggest the presence of a common pathway for the assembly of lncRNA-dependent nuclear bodies in mammalian cells.

SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies