English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

We read with interest the report of Takao and Miyakawa (1), who compare genomic responses to inflammatory challenges in humans and mice, reanalyzing the datasets originally reported by Seok et al. (2), but reaching a diametrically opposite conclusion. In line with its goal to establish the landscape of gene expression and regulation in the immune system, the ImmGen consortium has run focused human/mouse comparisons (3), and we also reanalyzed the datasets of Seok et al. We largely concur with the conclusions reached by Takao and Miyakawa, but wish to make a few additional points. Takao and Miyakawa point out computational issues in the article by Seok et al., and we agree with this assessment. The Pearson correlation is a simplistic and inadequate tool for such comparisons. Tools that assess the replication rate are far …

Genomic responses to inflammation in mouse models mimic humans: We concur, apples to oranges comparisons won’t do