Importance of the DNA “bond” in programmable nanoparticle crystallization

Significance The well-defined base-pairing interactions of DNA allow it to behave as a programmable bond on a nanoparticle scaffold and, when designed properly, these systems are able to form crystals through a process that closely mirrors the formation of atomic crystals. However, DNA-directed nanoparticle crystallization also offers a level of programmability that is not achievable in atomic systems as it enables precise and independent control over many components in a given system. This work focuses on understanding the nature of this DNA “bond,” how various parameters affect this bond, and the overall effects as seen through the crystallization behavior of the nanoparticles in an aggregate.