Open AccessMolecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αβ T cells
Author(s) -
Sobhan Roy,
Dalam Ly,
NanSheng Li,
John D. Altman,
Joseph A. Piccirilli,
D. Branch Moody,
Erin J. Adams
Publication year - 2014
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.1408549111
Subject(s) - cd1 , antigen presentation , cd1d , antigen , biology , mycobacterium tuberculosis , immunology , t cell , immune system , computational biology , tuberculosis , antigen presenting cell , t cell receptor , medicine , pathology
Significance Mycobacterium tuberculosis infects more than one-third of humans yet no effective vaccine exists. This study shows how a subset of αβ T cells targetsM. tuberculosis lipid antigens that are presented by the MHC molecule CD1c. In contrast to many T cells that recognize CD1d, these αβ T cells express diverse T-cell receptors and have differing footprints on CD1c during lipid recognition. This study also shows that some CD1c-specific αβ T cells are exquisitely specific for the lipid presented, whereas others have a more promiscuous reactivity, demonstrating that the αβ T-cell response to CD1c lipid presentation is diverse and adaptable. These data may provide additional resources for development of MHC-independent vaccines againstM. tuberculosis .
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