English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Peripheral nerve injury often occurs at axonal sites remote from the neuronal cell bodies. Information about these remote injuries must be accurately relayed back to the cell body as part of the reprogramming that occurs to transition the neuron to a regenerating state. We provide new insights into how the axonal endoplasmic reticulum (ER) proximal to the injury site generates a critical regeneration signal in sensory neurons. This involves injury-triggered activation and synthesis of an intraaxonal, ER transmembrane transcription factor, Luman/cAMP response element binding protein 3, that is retrogradely transported back into the nucleus. Manipulation of axon-derived Luman expression in injured sensory neurons reveals an important role for Luman in regulation of the intrinsic elongating form of axonal growth associated with the regeneration state.

Sensing nerve injury at the axonal ER: Activated Luman/CREB3 serves as a novel axonally synthesized retrograde regeneration signal