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Significance T7 phage has been used as a model system to study dsDNA virus capsid assembly and maturation. Yet, atomic capsid models and details of capsid transformations are not elucidated. From our cryo-EM study we have derived near-atomic resolutionreconstructions of the DNA-free procapsid, a DNA packaging intermediate, and the DNA-packaged, mature phage capsid. From these structures, we have derived the first near-atomic-level model of T7 capsid maturation. The structural knowledge obtained from this study can serve as a platform for analysis of other dsDNA viruses as well as a platform for the development of molecular tools such as improved phage display systems.

Capsid expansion mechanism of bacteriophage T7 revealed by multistate atomic models derived from cryo-EM reconstructions