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Significance Plasma cells (PCs) are terminally differentiated B cells that secret large amounts of antibodies to protect the host from infectious pathogens. Our study describes an important role for the adaptor protein Downstream-of-Kinase (DOK) 3 in promoting the differentiation of PCs by regulating the expression of programmed cell death 1 (PD-1) ligands PDL1 and PDL2. Moreover, we discover an unexpected role of calcium signalling in inhibiting the expressions of PD-1 ligands, and this inhibition is attenuated by DOK3. Knowing the signalling pathways that govern PC differentiation is critical for the optimal design of vaccines and adjuvants.

Adaptor protein DOK3 promotes plasma cell differentiation by regulating the expression of programmed cell death 1 ligands