Open AccessLong-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5
Author(s) -
TaeWan Kim,
Ri Cui,
Young-Jun Jeon,
Ji Hoon Lee,
JuHee Lee,
Hosung Sim,
Jong Kook Park,
Paolo Fadda,
Esmerina Tili,
Hiroshi Nakanishi,
Man-Il Huh,
Sung-Hak Kim,
Ju Hwan Cho,
Bong Hwan Sung,
Yong Peng,
Tae Jin Lee,
Zhenghua Luo,
Hui-Lung Sun,
Huijun Wei,
Hansjüerg Alder,
Jeong Su Oh,
Kang Sup Shim,
Sang-Bong Ko,
Carlo M. Croce
Publication year - 2014
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.1400350111
Subject(s) - enhancer , long non coding rna , biology , gene , genetics , non coding rna , computational biology , rna , gene expression
Significance Many cancer-associated variants have been found in the 8q24.21 region harboring enhancer activity. However, the functional mechanism of the variants is not clear due to the lack of protein-coding genes in the region and no significant correlation with the nearest oncogeneMYC . We identified long noncoding RNAs (lncRNAs) named cancer-associated region long noncoding RNAs (CARLo s) in the 8q24.21 region. Interestingly, we found that the cancer-associated variant rs6983267 regulating the enhancer activity is significantly associated with the expression of one of the lncRNAsCARLo-5 and thatCARLo-5 has an oncogenic function. By showing direct interaction between the enhancer region and active regulatory region of theCARLo-5 promoter, we provide a regulatory mechanism of cancer susceptibility caused by the cancer-associated variants.
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