English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Many cancer-associated variants have been found in the 8q24.21 region harboring enhancer activity. However, the functional mechanism of the variants is not clear due to the lack of protein-coding genes in the region and no significant correlation with the nearest oncogeneMYC . We identified long noncoding RNAs (lncRNAs) named cancer-associated region long noncoding RNAs (CARLo s) in the 8q24.21 region. Interestingly, we found that the cancer-associated variant rs6983267 regulating the enhancer activity is significantly associated with the expression of one of the lncRNAsCARLo-5 and thatCARLo-5 has an oncogenic function. By showing direct interaction between the enhancer region and active regulatory region of theCARLo-5 promoter, we provide a regulatory mechanism of cancer susceptibility caused by the cancer-associated variants.

Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5