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In a PNAS paper on the human connectome, Ingalhalikar et al. conclude that their “results reveal fundamental sex differences in the structural architecture of the human brain” and link these differences to behavioral sex differences (1). Others have previously referred to the difficulties in linking sex differences in brain structure to sex differences in behavior (2). We would like to focus here on the selective choice of data that forms the basis for such strong conclusions. Specifically, Ingalhalikar et al. claim that they have found “fundamentally different connectivity patterns in males and females” (1), with males having greater intrahemispheric connectivity and females, greater …

On the mis-presentation and misinterpretation of gender-related data: The case of Ingalhalikar’s human connectome study