English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Plasmodium falciparum is responsible for almost all malaria-related deaths and belongs to a family of parasites that infect African apes. In their native habitat, these parasites exhibit strict host tropism, with humanP .falciparum having never been found in wild-living chimpanzees and gorillas. Our research provides a molecular explanation for this phenomenon by showing that the interaction between a parasite protein (RH5) and its erythrocyte cell surface receptor (Basigin) is species specific and mirrors the observed host–parasite tropism. Our findings also reveal how a parasite responsible for one of the world’s major health problems has evolved its relationship with the human host and identify specific changes in the Basigin receptor that could make human erythrocytes resistant to infection byP .falciparum .

RH5–Basigin interaction plays a major role in the host tropism of Plasmodium falciparum