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Significance Caulobacter crescentus , a bacterium with an inherent asymmetric cell division, uses dynamic changes in chromosome methylation state to synchronize chromosome replication with cell-cycle regulation. We identified the N6 -methyladenine and 5-methylcytosine methylation state of every base pair at five times in the cell cycle to show that 4,515 GANTC sites, recognized by the CcrM methyltransferase, change from full- to hemimethylation upon passage of the replication fork. Significantly, 27 of the GANTC sites are protected from methylation at all times. We also identified four previously unknown methylation motifs and the cognate methyltransferase for two of these motifs. The ability to track the state of the methylome in exquisite temporal detail will be invaluable to investigations of microbial epigenetic regulation.

Global methylation state at base-pair resolution of the Caulobacter genome throughout the cell cycle