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Significance Daily rhythms in light coordinate many biological functions over the 24-h day, facilitating the adaptation of organisms to the environment. A crucial task accomplished routinely by all multicellular organisms is the maintenance of tissue homeostasis through the activity of adult stem cells, which generate new cells when required. Using a classicDrosophila stem cell niche, we show that the frequency of stem cell divisions is rhythmic in a day–night cycle. In addition, our data, which show that stem cell divisions are increased in a short-sleeping mutant, suggest that mechanisms regulating sleep–wake rhythms may also influence stem cell activity. Our findings provide links between environmental cycles, behavioral states, and maintenance of tissue integrity by stem cells.

Day–night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis