English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The article published by Cideciyan et al. (1) is an outstanding example of careful translational work. However, the concluding discussion warrants more thorough scrutiny. The authors proposed to increase the supply of chromophore (11-cis-retinal) to overcome the paradoxical improvement in visual function with continued photoreceptor degeneration seen in human patients with Leber congential amaurosis (LCA) treated by gene therapy. My own research on salamander retina warns against this approach. Specifically, we observed in isolated rod cells and in the intact neural retina that chromophore can cause rod cell degeneration and sprouting. Cell death (2) and sprouting (3) occurred if the receptor for chromophore, the …

Increased levels of gene therapy may not be beneficial in retinal disease