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We welcome interest in our work and encourage debate. As we have published previously (1), we agree with FitzGerald and coworkers (2) that those drugs that inhibit COX-2 have potential deleterious effects upon cardiovascular health, although we disagree with their conclusions that COX-2 drives prostacyclin release in healthy vessels or that we have omitted to cite relevant literature. Our paper in a recent issue of PNAS (3) contained references that represent the breadth of literature in this area, including two reviews from FitzGerald and coworkers and their most recent relevant study (4), and we encourage readers to read widely. We are aware that FitzGerald and coworkers believe urinary 2,3-dinor 6-keto PGF1α …

Reply to Ricciotti et al.: Evidence for vascular COX isoforms