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We are grateful to our colleagues at Cambridge for their attention (1) to our recent article (2). Our major goal therein was to report precise measurements of colloidal interactions caused by DNA handshaking. Because no detailed models for our system were available, we constructed a mean-field model, itself a significant refinement of one we published (3) in 2005. In contrast to previous comparisons of theory and experiment, our model and data agreed quantitatively, using reasonable values of DNA's physical (3) and thermodynamic (4) properties. We agree with the Cambridge group's conclusion that no existing theoretical framework can provide an exact description of this complicated physical situation. We are baffled, however, by the logic …

Reply to Mognetti et al.: DNA handshaking interaction data are well described by mean-field and molecular models