English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Myelin is the membranous structure that wraps around axonal segments and supports the fast saltatory conduction of action potentials along axons (1, 2). Disorders that disrupt myelin during development or in adulthood, such as multiple sclerosis, lead to severe pathologies, illustrating myelin's crucial role in normal neural functioning. In the central nervous system, oligodendrocytes (OLs) are the cell type responsible for producing myelin. An individual OL is multiprocessed and can myelinate up to 60 nearby axon segments, generating an incredibly complex cell morphology (3, 4). To achieve complete, yet nonredundant, myelination of neural circuits, there must be very accurate matching of myelin segments to axonal surfaces. How these intricate intercellular interactions are so precisely coordinated both temporally and spatially has been a long-standing and elusive question. A study reported in PNAS by Chong et al. (4) provides evidence for a competition-based mechanism of OL myelin refinement that signals via OL-derived Nogo-A during both development and remyelination after injury. In vivo, only OLs that make appropriate axonal contacts survive and initiate myelination (5). Therefore, it has long been recognized that competition for limited quantities of survival and inductive axonal cues is one mechanism driving myelin spatial refinement. Are there also repellant signals between neighboring OLs that further enhance this precise segregation? It has been previously demonstrated that the differentiation of OL-lineage cells can be modulated by factors such as oligodendrocyte precursor cell (OPC) …

A Nogo signal coordinates the perfect match between myelin and axons