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not available. The general principles involved in the preparation of the product are: 1. Dissolution of the gland by controlled acid hydrolysis. 2. Isoelectric fractionation of the active principle. It has been quite definitely proven that the hormone so obtained is a specific for parathyroid tetany in dogs. It has also been amply demonstrated that the physiological effect which the active principle exerts is related in the main to calcium metabolism. It has been found that the injection of the active extract into both normal and parathyroidectomized dogs causes a mobilization of calcium in the blood. The degree of increase of calcium in the blood is also directly related to the amount of the principle injected. A method of physiological standardization has been developed along these lines which permits of quite acc-urate determination of the potency of various extracts. Dr. E. P. Clark has most ably assisted in this research. Financial assistance has been afforded by a grant from the Carnegie Corporation which we wish most gratefully to acknowledge.

An Experimental Determination of the Critical Excitation Frequency for the Production of Fluorescent X-Radiation