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The recent study of tumor initiating cells (TICs) in a p53 null mammary tumor model by Zhang et al. (1) emphasizes that the selective activation of the Akt and canonical Wnt/β-catenin signaling pathways within the tumorigenic TICs plays a critical role in radiation resistance of TICs. Limiting dilution experiments are used to estimate and to compare TIC frequencies in their protocols. As such, limiting dilution transplantation assays (LDTAs) compose a substantial part of their work, and the authors claim that the related results provided strong support to their biological conclusions. Specifically, the results of LDTAs support the hypothesis of a very high frequency (≈1/27) of TICs among the LinnegCD29HighCD24High subpopulation as compared …

Radioresistance mechanisms of mammary tumor initiating cells: Unreliable biological conclusions based on limiting dilution assays