Open AccessGenome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription
Author(s) -
Arounie Tavenet,
Audrey Suleau,
Géraldine Dubreuil,
Roberto Ferrari,
Cécile Ducrot,
Magali Michaut,
Jean-Christophe Aude,
Giorgio Dieci,
Olivier Lefebvre,
Christine Conesa,
Joël Acker
Publication year - 2009
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.0900162106
Subject(s) - rna polymerase ii , transcription factor ii d , transcription (linguistics) , rna polymerase iii , transcription factor ii f , transcription factories , rna polymerase ii holoenzyme , biology , general transcription factor , transcription factor ii b , genetics , polymerase , rna polymerase , rna polymerase i , gene , microbiology and biotechnology , rna , promoter , gene expression , philosophy , linguistics
Human PC4 and the yeast ortholog Sub1 have multiple functions in RNA polymerase II transcription. Genome-wide mapping revealed that Sub1 is present on Pol III-transcribed genes. Sub1 was found to interact with components of the Pol III transcription system and to stimulate the initiation and reinitiation steps in a system reconstituted with all recombinant factors. Sub1 was required for optimal Pol III gene transcription in exponentially growing cells.
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