Open AccessA microRNA expression signature of human solid tumors defines cancer gene targets
Author(s) -
Stefano Volinia,
George A. Calin,
ChangGong Liu,
Stefan Ambs,
Amelia Cimmino,
Fabio Petrocca,
Rosa Visone,
Marilena V. Iorio,
Claudia Roldo,
Manuela Ferracin,
Robyn L. Prueitt,
Nozumu Yanaihara,
Giovanni Lanza,
Aldo Scarpa,
Andrea Vecchione,
Massimo Negrini,
Curtis C. Harris,
Carlo M. Croce
Publication year - 2006
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.0510565103
Subject(s) - microrna , biology , cancer research , cancer , gene , pancreatic cancer , oncogene , retinoblastoma , cell cycle , genetics
Small noncoding microRNAs (miRNAs) can contribute to cancer development and progression and are differentially expressed in normal tissues and cancers. From a large-scale miRnome analysis on 540 samples including lung, breast, stomach, prostate, colon, and pancreatic tumors, we identified a solid cancer miRNA signature composed by a large portion of overexpressed miRNAs. Among these miRNAs are some with well characterized cancer association, such as miR-17-5p, miR-20a, miR-21, miR-92, miR-106a, and miR-155. The predicted targets for the differentially expressed miRNAs are significantly enriched for protein-coding tumor suppressors and oncogenes (P < 0.0001). A number of the predicted targets, including the tumor suppressors RB1 (Retinoblastoma 1) and TGFBR2 (transforming growth factor, beta receptor II) genes were confirmed experimentally. Our results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes.
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