Open AccessLogic functions of the genomic cis-regulatory code
Author(s) -
Sorin Istrail,
Eric H. Davidson
Publication year - 2005
Publication title -
proceedings of the national academy of sciences of the united states of america
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.0409624102
Subject(s) - cis regulatory module , computational biology , repertoire , biology , unitary state , gene , computer science , regulation of gene expression , transcription (linguistics) , genetics , transcription factor , enhancer , political science , linguistics , philosophy , physics , acoustics , law
cis-Regulatory modules that control developmental gene expression process the regulatory inputs provided by the transcription factors for which they contain specific target sites. A prominent class of cis-regulatory processing functions can be modeled as logic operations. Many of these are combinatorial because they are mediated by multiple sites, although others are unitary. In this work, we illustrate the repertoire of cis-regulatory logic operations, as an approach toward a functional interpretation of the genomic regulatory code.