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Protein delivery to restricted plasma membrane domains is exquisitely regulated at different stages of the cell trafficking machinery. Traffic control involves the recognition of export/retention/retrieval signals in the endoplasmic reticulum (ER)/Golgi complex that will determine protein fate. A splice variant (SV), SV1, of the voltage- and Ca(2+)-activated K(+) channel alpha-subunit accumulates the channel in the ER, preventing its surface expression. We show that SV1 insert contains a nonbasic, hydrophobic retention/retrieval motif, CVLF, that does not interfere with proper folding and tetramerization of SV1. Localization of proteins in the ER by CVLF is independent of its position; originally, on the first internal loop, SV1 insert or CVLF perform equally well if placed at the middle or end of the alpha-subunit intracellular carboxyl terminus. Also, CVLF is able to restrict the traffic of an independently expressed transmembrane protein, beta 1-subunit. CVLF is present in proteins across species and in lower organisms. Thus, CVLF may have evolved to serve as a regulator of cellular traffic.

proceedings of the national academy of sciences of the united states of america

An endoplasmic reticulum trafficking signal prevents surface expression of a voltage- and Ca <sup>2+</sup> -activated K <sup>+</sup> channel splice variant

An endoplasmic reticulum trafficking signal prevents surface expression of a voltage- and Ca 2+ -activated K + channel splice variant

An endoplasmic reticulum trafficking signal prevents surface expression of a voltage- and Ca ²⁺ -activated K ⁺ channel splice variant