Open AccessLife extension in Drosophila by feeding a drug
Author(s) -
HyungLyun Kang,
Seymour Benzer,
KyungTai Min
Publication year - 2002
Publication title -
proceedings of the national academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.011
H-Index - 771
eISSN - 1091-6490
pISSN - 0027-8424
DOI - 10.1073/pnas.022631999
Subject(s) - biology , drosophila melanogaster , drosophila (subgenus) , psychological repression , acetylation , phenylbutyrate , gene , histone , genetics , period (music) , gene expression , microbiology and biotechnology , physiology , endocrinology , medicine , physics , acoustics
We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Flies fed PBA show a global increase in histone acetylation as well as a dramatically altered pattern of gene expression, including induction or repression of numerous genes. The delay in aging may result from the altered physiological state.
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