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Oral streptococci are known to modulate various physiological properties by responding to secreted signal peptide pheromones. These molecules accumulate in the environment and trigger a genetic response in the target cells at a threshold cell density, thereby synchronising a metabolic outcome with population density. In this review, we summarise how signal peptide pheromones of oral streptococci function. The possibility of targeting these peptide pheromones for the prevention of biofilm-associated infections such as dental caries is also discussed.

Signal peptide pheromones in oral streptococcal biofilms