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Six new anthraquinone-γ-pyrones, saliniquinones A-F ( 1 - 6 ), which are related to metabolites of the pluramycin/altromycin class, were isolated from a fermentation broth of the marine actinomycete Salinispora arenicola (strain CNS-325). Their structures were determined by analysis of one- and two-dimensional NMR spectroscopic and high-resolution mass spectrometric data. The relative and absolute configurations of compounds 1 - 6 were determined by analysis of NOESY NMR spectroscopic data and by comparison of circular dichroism and optical rotation data with model compounds found in the literature. Saliniquinone A ( 1 ) exhibited potent inhibition of the human colon adenocarcinoma cell line (HCT-116) with an IC 50 of 9.9 × 10 -9 M. In the context of the biosynthetic diversity of S. arenicola , compounds 1 - 6 represent secondary metabolites that appear to be strain specific and thus occur outside of the core group of compounds commonly observed from this species.

Saliniquinones A - F, New Members of the Highly Cytotoxic Anthraquinone-γ-Pyrones from the Marine Actinomycete Salinispora arenicola